Bioactive Small Molecules
Cayman Chemical ANTIBODY BIapenm 10mg
A broad-spectrum β-lactam antibiotic; active against aerobic and anaerobic, Gram-positive and Gram-negative bacteria, including clinical isolates of E. coli, oxacillin-sensitive S. aureus, B. fragilis, and Clostridium (MIC90s = 0.12, 0.12, 0.25, and 1 μg/ml, respectively); active against the rifampicin-susceptible H37Rv and rifampicin-resistant 115R and 124R M. tuberculosis strains (MICs = 2-4, 4-8, and 8-16 mg/L, respectively); decreases the number of lung CFUs in a mouse model of M. tuberculosis infection at 200 mg/kg
Cayman Chemical ANTIBODY CCT007093 25mg
A PP1D inhibitor (IC50 = 8.4 µM); selectively reduces colony formation in MCF-7 and MCF-3B cells that overexpress PP1D over HeLa cells that express wild-type levels of PPD1D (IC50s = 0.48, 0.13, and >50 µM, respectively); active against T. cruzi epimastigotes (IC50 = 6.5 µM)
TARGETMOL CHEMICALS INC TCS JNK 5a 5mg
TCS JNK 5a is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).
Medchemexpress LLC C004019 | 2417159-57-8 | 99.7% | 1035.29 | 100 MG
C004019 is a BBB-penetrable, small-molecule PROTAC designed to target tau protein. It works by recruiting tau and E3 ligase simultaneously, promoting the ubiquitination and proteasome-dependent degradation of tau. This action has been shown to improve synaptic and cognitive functions in Alzheimer's disease (AD) mice, making it suitable for research in AD and tau protein-related diseases.
- Does not significantly affect viability of HEK293 cells.
- Inhibits expression of total tau and phosphorylated tau in HEK293-hTau and SH-SY5Y cells.
- Reduces tau protein levels in the brains of wild-type and 3xTg-AD mice.
- Promotes tau clearance and improves cognitive and synaptic functions in hTau and 3xTg-AD mice.
- Ameliorates cognitive functions and dendritic plasticity.
Cayman Chemical ANTIBODY GR79236 1mg
A selective adenosine A1 receptor agonist (Kis = 3.1 and 1,300 nM for adenosine A1 and A2 receptors, respectively, in rat brain; inhibits isoprenaline-induced cAMP accumulation in DDT1MF-2 hamster smooth muscle cells (IC50 = 2.6 nM) but only decreases contractility in isolated guinea pig atria with an EC50 value of 1,500 nM; inhibits norepinephrine-induced lipolysis in rat adipocytes (EC50 = 0.83 nM); decreases locomotor activity and inhibits DMCM-induced seizures in mice (ED50s = 0.13 and 0.3 mg/kg, respectively); decreases blood pressure by 74% in anesthetized rats at 0.1 mg/kg
Cayman Chemical ANTIBODY FlumequIn 25g
A fluoroquinolone antibiotic; active against S. aureus, S. pyogenes, B. subtilis, E. coli, P. aeruginosa, S. faecalis, and K. pneumoniae (MICs = 1-100 UG/ml); active against field isolates of B. hyodysenteriae (MICs = 6.25-200 UG/ml); increases survival in rat models of P. vulgaris-induced urinary tract infection and P. mirabilis-induced prostatitis at 50 mg/kg
Cayman Chemical ANTIBODY UC2288 5mg
A p21WAF1 inhibitor; reduces the protein levels and mRNA expression of p21WAF1 independently of Raf and p53, respectively, at 10 µM; decreases the proliferation of, and phosphorylation of EGFR and ERK1/2 in, CNE-2 and 5-8F cell lines at 8 µM; reduces tumor growth and induces apoptosis in an HCT116 colorectal cancer mouse xenograft model at 15 mg/kg three times per week in combination with imetelstat
Medchemexpress LLC 5,6-dibromo-4-nitro-2-piperidin-4-yl-1-propan-2-ylbenzimidazole | 1616359-00-2 | 99.0% | 1G
5,6-dibromo-4-nitro-2-piperidin-4-yl-1-propan-2-ylbenzimidazole | 1616359-00-2 | 99.0% | 1G
TARGETMOL CHEMICALS INC Solcitinib 10mg
Solcitinib (GSK2586184, GLPG0778) is a JAK1 inhibitor. Solcitinib may be potentially used for the treatment of psoriasis, ulcerative colitis, and systemic lupus erythematosus.
Cayman Chemical ANTIBODY RM 133-3 10mg
An ionizable cationic lipid; has been used in the formation of LNPs for the delivery of mRNA in vivo; LNPs containing RM 133-3 and encapsulating human EPO mRNA increase serum human EPO protein levels in mice
Cayman Chemical 2-fluoro MBZPhydrochlorIde 5mg
An analytical reference standard categorized as a piperazine; intended for research and forensic applications
Apexbio Technology LLC Buparvaquone, 100mg CAS# 88426-33-9
Buparvaquone is an analog of the antimalarial hydroxynaphthoquinones. It is applicable for the therapy and prophylaxis of Theileriosis and exhibits an anti-Leishmanial activity. Other sizes are also available. Please inqury us for quote.
Selleck Chemical LLC Recilisib E2947-25MG
Recilisib (ON01210 EX-RAD) is a radioprotectant that activates the activity of AKT and PI3K in cells It has been studied as prophylactic (use prior to radiation exposure) and therapeutic (after exposure to radiation) drug
Selleck Chemical LLC Ginsenoside F1 S9299-1MG
Ginsenoside F1 a pharmaceutical component of ginseng is known to have antiaging antioxidant anticancer and keratinocyte protective effects Ginsenoside F1 exhibits competitive inhibition of the activity of CYP3A4 with Ki values of 67 8 16 2 M Ginsenoside F1 also exhibited a weaker inhibition of the activity of CYP2D6
Cayman Chemical ANTIBODY BRD7389 10mg
An inhibitor of RSKs (IC50s = 1.5, 2.4, and 1.2 μM for RSK1, RSK2, and RSK3, respectively); causes mouse αTC1 pancreatic α cells to adopt several morphological and gene expression features of β cells, including increased insulin expression